Crystallisation and Structure Determination
Publications
Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Arroyo A. G. & Sagi I. (2015).
Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.Structure.2015 Jan 6
,
23
(1):104-115.
Zimhony O., Schwarz A., Raitses-Gurevich M., Peleg Y., Dym O., Albeck S., Burstein Y. & Shakked Z. (2015).
AcpM, the meromycolate extension Acyl carrier protein of mycobacterium tuberculosis, is activated by the 4′-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.Biochemistry.2015 Apr 14
,
54
(14):2360-2371.
Sela-Passwell N. A., Kikkeri R., Dym O., Rozenberg H., Margalit R., Arad-Yellin R., Eisenstein M., Brenner O., Shoham T., Danon T., Shanzer A. & Sagi I. (2012).
Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.Nature Medicine.2012 Jan
,
18
(1):143-147.
Li M., Greenblatt H. M., Dym O., Albeck S., Pais A., Gunanathan C., Milstein D., Degani H. & Sussman J. (2011).
Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators.Journal of Medicinal Chemistry.2011 May 26
,
54
(10):3575-3580.
Khersonsky O., Roethlisberger D., Wollacott A. M., Murphy P., Dym O., Albeck S., Kiss G., Houk K. N., Baker D. & Tawfik D. (2011).
Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution.Journal of Molecular Biology.2011 Apr
,
407
(3):391-412.
Karanicolas J., Com J. E., Chen I., Joachimiak L. A., Dym O., Peck S. H., Albeck S., Unger T., Hu W., Liu G., Delbecq S., Montelione G. T., Spiegel C. P., Liu D. R. & Baker D. (2011).
A De Novo Protein Binding Pair By Computational Design and Directed Evolution.Molecular Cell.2011 Apr 22
,
42
(2):250-260.
Goihberg E., Peretz M., Tel-Or S., Dym O., Shimon L., Frolow F. & Burstein Y. (2010).
Biochemical and structural properties of chimeras constructed by exchange of cofactor-binding domains in alcohol dehydrogenases from thermophilic and mesophilic microorganisms.Biochemistry.2010 Mar 9
,
49
(9):1943-1953.
Khersonsky O., Röthlisberger D., Dym O., Albeck S., Jackson C. J., Baker D. & Tawfik D. S. (2010).
Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the ke07 series.Journal of Molecular Biology.2010,
396
(4):1025-1042.
Grossman M., Tworowski D., Dym O., Lee M., Levy Y., Murphy G. & Sagi I. (2010).
The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function.Biochemistry.2010 Jul 27
,
49
(29):6184-6192.
Dym O., Albeck S., Peleg Y., Schwarz A., Shakked Z., Burstein Y. & Zimhony O. (2009).
Structure-Function Analysis of the Acyl Carrier Protein Synthase (AcpS) from Mycobacterium tuberculosis.Journal of Molecular Biology.2009 Nov 6
,
393
(4):937-950.
Röthlisberger D., Khersonsky O., Wollacott A. M., Jiang L., DeChancie J., Betker J., Gallaher J. L., Althoff E. A., Zanghellini A., Dym O., Albeck S., Houk K. N., Tawfik D. S. & Baker D. (2008).
Kemp elimination catalysts by computational enzyme design.Nature.2008 May 8
,
453
(7192):190-195.
Liberman N., Dym O., Unger T., Albeck S., Peleg Y., Jacobovitch Y., Branzburg A., Eisenstein M., Marash L. & Kimchi A. (2008).
The Crystal Structure of the C-Terminal DAP5/p97 Domain Sheds Light on the Molecular Basis for Its Processing by Caspase Cleavage.Journal of Molecular Biology.2008 Nov 14
,
383
(3):539-548.