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יוני 22, 2015
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Date:27רביעיאפריל 2022הרצאה
Representation of 3D space in the mammalian brain: From 3D grid cells in flying bats to 3D perception in flying humans
More information שעה 12:30 - 13:30כותרת Student Seminar - PhD Thesis Defense FRONTALמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Gily Ginosar
Prof. Nachum Ulanovsky Lab Dept of Brain Sciences, WISמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about While our world is three-dimensional (3D), spatial perceptio...» While our world is three-dimensional (3D), spatial perception is most often studied in animals and humans navigating across 2D surfaces. I will present two cases in which the consideration of the 3D nature of the world has led us to surprising results. The first case regards the neural recording of mammalian grid cells. Grid cells that are recorded over 2D surfaces create a hexagonal-shaped repetitive lattice, which inspired many theoretical studies to investigate the pattern’s mechanism and function. Upon recording in bats flying through 3D space, we found that grid cells did not exhibit a hexagonal global lattice, but rather showed a local order – with grid-fields exhibiting fixed local distances. Our results in 3D strongly argue against most of the prevailing models of grid-cell function, and we suggest a unified model that explains the results in both 2D and 3D. The second case regards the perception of 3D space in humans. Different behavioral studies have shown contradicting evidence of human perception of 3D space being either isotropic or vertically compressed. We addressed this question using human experts in 3D motion and navigation – fighter pilots – studied in a flight simulator. We considered two aspects of the perception of 3D space: surrounding space and travelled space. We show that different aspects of the perception of space are shaped differently with experience: whereas the perception of the 3D surrounding space was vertically compressed in both expert and non-expert subjects, fighter pilots exhibited isotropic perception of travelled space, whereas non-expert subjects retained a distorted perception. Together, our research sheds light on the differences and similarities between the coding of 3D versus 2D space, in both animals and humans.
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Date:28חמישיאפריל 2022הרצאה
“Spin-orbit coupling and Kondo resonance in Co adatom on Cu(100) surface: DFT+ED study”
More information שעה 11:00 - 12:00מיקום בניין פרלמן למדעי הכימיהמרצה Prof. Alexander B. Shick
Institute of Physics, the Czech Academy of Science, Pragueמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about The studies of magnetic atoms adsorbed on non-magnetic surfa...» The studies of magnetic atoms adsorbed on non-magnetic surfaces provide a fundamental insights into the quantum many-body phenomena at the nanoscale. They imprint non-trivial signatures in STM measurements, and can serve as a prototype for potential applications in quantum information technology.
Our work aims at the investigation of the electronic structure, spin and orbital magnetic character for the Co adatom on the top of Cu(100) surface. We make use of DFT combined with exact diagonalization of the multi-orbital Anderson impurity model, including the spin-orbit coupling.
For the Co atom d-shell occupation nd=8, a singlet many-body ground state and Kondo resonance are found, when the spin-orbit coupling is included in the calculations. The differential conductance is evaluated in a good agreement with the STM measurements. This comparison is the most direct way to demonstrate the validity of our theoretical approximation. Our results illustrate the very essential role which the spin-orbit coupling is playing in a formation of Kondo singlet for the multi-orbital impurity in low dimensions.
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Date:28חמישיאפריל 2022הרצאה
Killing Cancer Stem Cells
More information שעה 14:00 - 15:00מרצה Jeremy Rich, MD, MHS, MBA
Affiliation: UPMC Hillman Cancer Center Pittsburgh Foundation Chair in Personalized Cancer Therapy Professor of Neurology University of Pittsburgh School of Medicine, Pennsylvania, USAמארגן המכון לחקר הטיפול בסרטן עש דואקצרו קשר -
Date:02שנימאי 2022כנסים
Systems Biology & Immunology Symposium - the two worlds of Nir Friedman
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Steffen Jungמארגן המחלקה לאימונולוגיה מערכתית -
Date:02שנימאי 2022סימפוזיונים
Probing Biomolecular Dynamics with Single-Molecule Spectroscopy
More information שעה 11:00 - 12:15מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Hagen Hofmann
Department of Chemical & Structural Biology, WISמארגן הפקולטה לכימיהצרו קשר תקציר Show full text abstract about Explaining organisms in terms of the jiggling and wiggling o...» Explaining organisms in terms of the jiggling and wiggling of atoms is a central goal in molecular biology. Yet, the dynamics of proteins with their sophisticated three-dimensional architectures exceeds the capabilities of analytical theories. On the other hand, intrinsically disordered proteins are often well described by polymer theories of different flavors. However, these theories do not apply to proteins in which disorder and order mix. Combining structural biology with polymer theory is therefore required to understand such biomolecules. I will discuss how optical single-molecule spectroscopy allows us to probe the dynamics of (partially) disordered proteins and complexes from nanoseconds to milliseconds. I will show how many weak protein-protein interactions can cause rugged energy landscapes that slow-down dynamics by orders of magnitude. In the second part, I will discuss how we envision to bridge scales between molecules and cells at the example of a cellular phenotype switch that requires a dynamic interplay between proteins and DNA. While single-molecule tools to probe the kinetics of biomolecules are well developed, similar approaches to study the dynamics of cellular processes such as gene expression are scarce. In the final part of my talk I will therefore present a new approach to tackle this problem using single-particle tracking -
Date:02שנימאי 2022הרצאה
Growing structural proteins into advanced materials for food security
More information שעה 15:00 - 16:00כותרת SAERI Lecture- Sustainability and Energy Research Initiative lecture seriesמיקום via zoomמרצה Prof. Benedetto Marelli
Department of Civil and Environmental Engineering, Massachusetts Institute of Technology (MIT), USAמארגן בית הספר למחקר - מכון ויצמן למדעצרו קשר -
Date:03שלישימאי 2022הרצאה
TBA
More information שעה 11:00 - 11:00מיקום https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09מרצה Mathew Henry מארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר -
Date:03שלישימאי 2022הרצאה
Models of Human Memory
More information שעה 12:30 - 13:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Misha Tsodyks
Dept of Brain Sciences, WISמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about Human memory is a multi-stage process that in real life cann...» Human memory is a multi-stage process that in real life cannot be easily quantified let alone predicted by any kind of mathematical model. Cognitive psychologists developed experimental paradigms to overcome the first problem by using randomly assembled lists of words or other items for recognition and recall. Results of these experiments can be precisely characterized, and we recently proposed a set of mathematical models that are based on simple assumptions that can be analytically solved and provide surprisingly accurate predictions tested on Amazon Mechanical Turk internet platform. The main innovation of this approach to modeling memory is that (i) it is based on a very small set of basic principles and has little to no free parameters and (ii) assumes deterministic processes underlying memory. In particular, our recall model results in the prediction with not a single free parameter, indicating full universality of this memory component. Our model for forgetting has one free integer parameter, and indeed our experiments show that different types of items exhibit different rate of forgetting. The most ambitious part of this project is to generalize the quantitative approach to memory to more meaningful material such as narratives. We are designing quantitative measures of performance in these experiments. Our preliminary results indicate interesting features of performance for meaningful material, in particular the recall is more structured and uniform across subjects. We believe that better understanding of memory processes with meaningful material will allow the future AI systems to achieve a better and more ‘human’ level of processing of natural language. -
Date:03שלישימאי 2022הרצאה
Beyond NGS: Single-molecule epigenomics
More information שעה 14:00 - 15:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Yuval Ebenstein
School of Chemistry Tel-Aviv Universityמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:08ראשוןמאי 202210שלישימאי 2022כנסים
2020 Dan Andreae Conference on "Mechanisms of experience-dependent plasticity: connecting genes, cells and circuits in the visual system."
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Ivo Spiegel -
Date:08ראשוןמאי 2022הרצאה
TBA
More information שעה 11:00 - 11:00מיקום https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09מרצה Nili Harnik
Tel Aviv Universityמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר -
Date:08ראשוןמאי 2022הרצאה
Molecular Genetics Departmental seminar
More information שעה 13:00 - 14:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Yehuda Danino & Tslil Braun מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:09שנימאי 202210שלישימאי 2022הרצאה
Molecular Genteics departmental retreat
More information שעה כל היוםמארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:09שנימאי 2022סימפוזיונים
Repurposing the chemistry of life for nanotechnology
More information שעה 11:00 - 12:15מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Rein V. Ulijn
Advanced Science Research Center, City University of New Yorkמארגן הפקולטה לכימיהדף בית צרו קשר תקציר Show full text abstract about We are interested in how functionality emerges from interact...» We are interested in how functionality emerges from interactions between biomolecules, and subsequently how these functions can be incorporated into materials.1 Instead of using sequences known in biological systems, we use unbiased computational2 and experimental3 approaches to search and map the peptide sequence space for specific interactions and functions, with a focus on side chain, instead of backbone interactions. The talk will explore how to program molecular order and disorder through side chain interactions in short peptides4, and how the conformations adopted by these peptides can be exploited to regulate interfacial assembly properties, and liquid-liquid phase separation. We will discuss chemo-mechanical peptide-crystals with connected soft and stiff domains, that change their properties upon changes in hydration states.5 The last part of the talk will focus on our progress in holistic study of mixtures of molecules that individually are simple and non-functional, but as components of complex interacting systems, however, they give rise to self-organization patterns that are dictated by the environmental conditions.6 Collectively, we expect to identify insights that allow the repurposing of nature's molecules to design new functions that currently are not known in biology. -
Date:10שלישימאי 2022הרצאה
Balanced activities of Atg2 and Atg24 regulate opening of the autophagic isolation membrane rim
More information שעה 10:00 - 10:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Autophagy targets cytosolic portions to lysosomal degradatio...» Autophagy targets cytosolic portions to lysosomal degradation by sequestration into a de novo built isolation membrane. Using novel tools for molecular genetics in budding yeast, I show that these membranes expand in the shape of a round amphora with a narrow opening at the rim. Partial loss of Atg2 leads to widening of the rim by in situ activity of Atg24. Interestingly, Atg24 also promotes inflation of the autophagic vesicle and sequestration of large cargo. My work thus suggests a new topological model for isolation membrane expansion, wherein tight regulation of the rim by distinct molecules governs both the shape and the cargo of the autophagic vesicle. -
Date:10שלישימאי 2022הרצאה
Ambient Imaging of Biological Samples Using Nanospray Desorption Electrospray Ionization (nano-DESI) Mass Spectrometry
More information שעה 12:30 - 12:30מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Prof. Julia Laskin
Department of Chemistry Purdue Universityמארגן המחלקה לתשתיות מחקר מדעי החייםצרו קשר -
Date:11רביעימאי 2022הרצאה
Transcription Drive Development Minisymposium
More information שעה 10:30 - 15:00מיקום אולם ע"ש דולפי ולולה אבנרמארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:11רביעימאי 2022הרצאה
Seminar for Thesis Defense
More information שעה 14:00 - 15:00כותרת "A short non-coding HBV RNA region upregulates R2 by eliciting the cellular DNA damage response"מיקום Botnar Auditorium. Belfer building & zoomמרצה Dr. Karin Broennimann מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:12חמישימאי 2022הרצאה
What’s new in the Drug Discovery and Medicinal Chemistry unit
More information שעה 09:00 - 09:00מיקום via ZOOMמרצה Dr. Leo Solmesky, Dr. Noga Kozer, Dr. Khriesto Shurrush מארגן המחלקה לתשתיות מחקר מדעי החייםדף בית צרו קשר -
Date:12חמישימאי 2022הרצאה
The awesome power of fluorine NMR - from drugs to cells
More information שעה 09:30 - 10:30מרצה Prof. Angela M. Gronenborn, Ana Naamat
Department of Structural Biology at the University of Pittsburgh.מארגן מכון קלור לדימות וספקטרוסקופיה של תהודה מגנטית בעוצמות גבוהותצרו קשר תקציר Show full text abstract about Nuclear magnetic resonance (NMR) spectroscopy is a versatile...» Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for probing structure, dynamics, folding, and interactions at atomic resolution. While naturally occurring magnetically active isotopes, such as 1H, 13C, or 15N, are most commonly used in biomolecular NMR, with 15N and 13C isotopic labeling routinely employed at the present time, 19F is a very attractive and sensitive alternative nucleus, which offers rich information on biomolecules in solution and in the solid state. This presentation will summarize the unique benefits of solution and solid-state 19F NMR spectroscopy for the study of biomolecular systems. Particular focus will be placed on the most recent studies and on unique and important potential applications of fluorine NMR methodology.