Pages
נובמבר 30, 2015
-
Date:29שלישיאוקטובר 2019הרצאה
'Stem Cells, Regeneration and Aging Breakfast Seminar with Prof. Steffen Jung
More information שעה 09:00 - 10:00כותרת Stem Cells, Regeneration and Aging Breakfast Seminarמיקום בניין ע"ש מקס ולילאן קנדיוטימארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:29שלישיאוקטובר 2019הרצאה
"New Directions for Electricity and Fuels from Sunlight
More information שעה 11:00 - 12:30כותרת Prof.Israel Rubinstein Memorial Lectureמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Harry Atwater
Howard Hughes Professor and Professor of Applied Physics and Materials Science Director, Joint Center for Artificial Photosynthesis California Institute of Technologyמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about The recent rapid, global growth of photovoltaics has moved s...» The recent rapid, global growth of photovoltaics has moved scientific research frontiers for solar energy conversion towards new opportunities including i) ultrahigh efficiency photovoltaics (η > 30%) and ii) direct synthesis of energy-dense chemical fuels from sunlight, including hydrogen and products from reduction of carbon dioxide. I will illustrate several examples of how design of materials for light harvesting, charge transport and catalytic selectivity can enable advances in electricity and fuel synthesis. Photonic design has opened new directions for high efficiency photovoltaics and luminescent solar concentrators. Semiconductors coupled to water oxidation and reduction catalysts have enabled approaches to photoelectrochemical solar-to-hydrogen generation with >19% efficiency using artificial photosynthetic structures. Solar-driven reduction of carbon dioxide presents both an enormous opportunity and challenge because of the need for selectivity in generating useful multi-carbon products by multiple electron and multi-proton transfer steps. Present work and future directions in selective photocatalytic and photo-electrocatalytic materials for artificial photosynthesis aimed at catalytic reduction of carbon dioxide will be discussed.
-
Date:29שלישיאוקטובר 2019הרצאה
Mass spectrometry reveals the chemistry of formaldehyde cross-linking in structured proteins
More information שעה 14:00 - 15:00מיקום בניין הלן ומילטון קימלמןמרצה Dr. Nir Kalisman
Dept. of Biological Chemistry The Hebrew Universityמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:29שלישיאוקטובר 2019הרצאה
"Sporadic Alzheimer's disease – does it start with altered ubiquitin signaling?”
More information שעה 14:00 - 14:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Michael H. Glickman
Department of Biology, Technion, Haifaמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about With our rapidly aging population, Alzheimer’s disease (AD) ...» With our rapidly aging population, Alzheimer’s disease (AD) is often considered the plague of the 21st century. While much is known regarding the direct genetic mutations that trigger the rare familial form of the disease (FAD), molecular mechanisms driving the emergence of late-onset sporadic AD (SAD) remain elusive. A distinctively human predicament, AD is a protein-based disease characterized by toxic protein build up in the brain. The principal mechanisms for protein turnover or removal are dependent on ubiquitin. We will describe evidence that interference with ubiquitin signalling in a 3-dimentional human neuronal culture is sufficient to cause the two pathological hallmarks of AD (A plaques and neurofibrillary tangles), even in the absence of any familial mutations. By utilizing this platform, we specifically demonstrate that attenuated ubiquitin-dependent turnover leads to elevated levels of the Amyloid Precursor Protein (APP), enhanced secretion of the toxic amyloid-β42 peptide, and extra-cellular amyloid plaque build-up. Furthermore, we demonstrate that impaired ubiquitin signalling is a common feature of different human and murine models of AD, whereas overcoming this impairment is sufficient to decrease formation of A plaques and neurofibrillary tangles in an experimental model of FAD. To summarise, our work uncovers a role for ubiquitin during the early “cellular phase” of neurodegeneration that underlies emergence and progression of AD, providing hope that tweaking components of the ubiquitin-proteasome system has the potential to decrease risk for developing AD pathology, opening up new therapeutic approaches. -
Date:30רביעיאוקטובר 2019הרצאה
Seminar for thesis defense Naama Dekel
More information שעה 13:00 - 14:00כותרת System level study of the cell death functional signature in metastatic melanoma cell linesמיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Naama Dekel מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:31חמישיאוקטובר 2019כנסים
Mini-Symposium on Demystifying machine learning for microscopy
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Ofra Golaniדף בית -
Date:31חמישיאוקטובר 2019הרצאה
Characterization of Biomolecule and Structure Changes using Polarization Transfer from Hyperpolarized Water
More information שעה 09:30 - 10:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Jihyun Kim
Department of Chemistry ,Texas A&M Universityמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Nuclear magnetic resonance (NMR) spectroscopy is a powerful ...» Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool for the characterization of protein structure and intermolecular interactions. However, NMR is not readily applicable to determine fast structural changes and weak interactions between molecules because of low signal sensitivity and time requirements to record multi-dimensional NMR spectra. To overcome these limits, the hyperpolarization technique of dissolution dynamic nuclear polarization (D-DNP) is combined with NMR. Not all molecules can be directly hyperpolarized. Instead, polarization transfer from hyperpolarized small molecules to a target of interest can be utilized as a means of obtaining polarization, as well as for detecting intermolecular interactions between these molecules Here, hyperpolarized water-assisted NMR spectroscopy was developed to measure intermolecular interactions with water. Firstly, the use of DNP hyperpolarization was demonstrated for the accurate determination of intermolecular cross-relaxation rates between hyperpolarized water and fluorinated target molecules.[1]
Because hyperpolarized water acts as a source spin with a large deviation of the population from the equilibrium, the 19F signal on the target molecules is enhanced through NOE, allowing obtain an entire NOE buildup curve in a single, rapid measurement. When the hyperpolarized water-assisted NMR experiment is applied to a protein, water hyperpolarization can be transferred to amide protons on the protein through proton exchange. Further, this polarization spreads within the protein through intramolecular NOE to nearby protons including aliphatic groups.[2] By utilizing this polarization transfer, this method extends to measure enhanced 2D NMR spectra of the protein under folded and refolding conditions.[3] With the ability to rapidly measure protein signals that were enhanced through transferred polarization from hyperpolarized water, NMR spectra can be acquired within the timescale of the protein folding. Compared to the folded protein experiment, signals attributed to exchange-relayed NOEs are not observable in the refolding experiment (Figure 1b). These differences are explained by the absence of long-range contacts with nearby exchangeable protons such as OH protons
-
Date:31חמישיאוקטובר 2019הרצאה
The Barry Sherman Medicinal Chemistry and Chemical Biology Seminar Series Transnational Cancer Research
More information שעה 14:00 - 15:00כותרת Converging Cancer Genetics, Structural Biology and Medicinal Chemistryמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Daniel Rauh
Faculty of Chemistry and Chemical Biology, TU Dortmund University, Germanyצרו קשר -
Date:03ראשוןנובמבר 201907חמישינובמבר 2019מועצת המנהלים הבינלאומית
ישיבות הועדה המדעית האקדמית המייעצת, 2019
More information שעה כל היוםמיקום מרכז כנסים על-שם דויד לופאטיצרו קשר -
Date:03ראשוןנובמבר 2019כנסים
Pre-SAAC symposium on Systems Biology
More information שעה 09:00 - 14:30מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Uri Alon -
Date:03ראשוןנובמבר 2019הרצאה
Pre-SAAC symposium on: New perspectives in modern mathematics
More information שעה 09:30 - 17:00מיקום בניין יעקב זיסקינדמארגן המחלקה למתמטיקהדף בית צרו קשר -
Date:03ראשוןנובמבר 2019הרצאה
Annual Zuckerman Symposium
More information שעה 10:00 - 14:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיודף בית צרו קשר -
Date:03ראשוןנובמבר 2019הרצאה
Ocean Worlds of the Outer Solar System: Life as we know it or life as we don’t?
More information שעה 11:00 - 11:00מיקום בניין משפחת זוסמןמרצה Alex Hayes
Associate Professor, Director, Cornell Center for Astrophysics and Planetarty Science, Director of the Spacecraft Planetary Image Facilityמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר תקציר Show full text abstract about Recent discoveries have shown that habitable environments li...» Recent discoveries have shown that habitable environments likely exist in subsurface water oceans within the outer planet moons of Europa and Enceladus. On Titan, the largest moon of Saturn, lakes and seas of liquid hydrocarbon exist in addition to a vast subsurface water ocean. These places represent ideal locations for hydrothermal environments that could sustain life as we know it and, in Titan’s case, perhaps even life as we don’t. The next generation of uncrewed planetary spacecraft will be designed to search for the signs of life in one or more of these worlds. This lecture will begin with a brief review of the discoveries that have motivated a renewed importance for Ocean World exploration, before diving into Titan's lakes and seas to discuss recent findings related to its hydrocarbon-based hydrologic cycle and setting the stage for the newly selected Dragonfly quadcopter set to explore Titan in the mid 2030s. -
Date:03ראשוןנובמבר 2019הרצאה
Transmission Electron Microscopy in Motion
More information שעה 11:00 - 12:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Frances M. Ross
Department of Materials Science and Engineering, MITמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about We can watch crystals grow in the electron microscope by add...» We can watch crystals grow in the electron microscope by adding atoms one at a time onto a clean surface. The movies tell us about kinetics and thermodynamics but can also be entertaining, frustrating, or both at the same time. I will attempt to share the joy of this type of “in situ” microscopy as we aim to understand how atoms assemble into nanowires or nanocrystals and use the information to control the formation of more complicated nanostructures with new properties -
Date:05שלישינובמבר 2019הרצאה
Stress-induced psychiatric disorders: A symphony of molecular and cellular mechanisms
More information שעה 10:00 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Prof. Alon Chen
Department of Neurobiology - WISמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about The biological response to stress is concerned with the main...» The biological response to stress is concerned with the maintenance of homeostasis in the presence of real or perceived challenges. This process requires numerous adaptive responses, involving changes in the central nervous and neuroendocrine systems. When a situation is perceived as stressful, the brain activates many neuronal mechanisms and circuits, linking centers involved in sensory, motor, autonomic, neuroendocrine, cognitive, and emotional functions in order to adapt to the demand. However, the details of the pathways by which the brain translates stressful stimuli into the final, integrated biological response are not completely understood. Nevertheless, it is clear that dysregulation of these physiological responses to stress can have severe psychological and physiological consequences, and there is substantial evidence to suggest that inappropriate regulation, disproportional intensity, or chronic and/or irreversible activation of the stress response is linked to the etiology and pathophysiology of anxiety, depression and metabolic-related disorders. The lecture will review our recent knowledge and findings of stress response neurobiology and stress-induced psychiatric disorders. -
Date:05שלישינובמבר 2019הרצאה
Microbial community maintenance of plant growth: bridging the gap between ecology and mechanism
More information שעה 11:30 - 12:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dr. Omri Finkel
Grant-Dangl Lab, Biology Department, University of North Carolina-Chapel Hill, USAמארגן המחלקה למדעי הצמח והסביבהדף בית צרו קשר -
Date:05שלישינובמבר 2019הרצאה
Collective Conflict Resolution in Groups on the Move
More information שעה 12:30 - 12:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Nir Gov
Dept of Chemical and Biological Physics Faculty of Chemistry, WISמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about Collective decision-making regarding direction of travel is ...» Collective decision-making regarding direction of travel is observed during natural motion of animal and cellular groups. This phenomenon is exemplified, in the simplest case, by a group that contains two informed subgroups that hold conflicting preferred directions of motion. Under such circumstances, simulations, subsequently supported by experimental data with birds and primates, have demonstrated that the resulting motion is either towards a compromise direction or towards one of the preferred targets (even when the two subgroups are equal in size). However, the nature of this transition is not well understood. We present a theoretical study that combines simulations and a spin model for mobile animal groups. This allows us to identify the nature of this transition at a critical angular difference between the two preferred directions: in both flocking and spin models the transition coincides with the change in the group dynamics from Brownian to persistent collective motion. The groups undergo this transition as the number of uninformed individuals (those in the group that do not exhibit a directional preference) increases, which acts as an inverse of the temperature (noise) of the spin model. When the two informed subgroups are not equal in size, there is a tendency for the group to reach the target preferred by the larger subgroup. We find that the spin model captures effectively the essence of the collective decision-making transition and allows us to reveal a noise-dependent trade-off between the decision-making speed and the ability to achieve majority (democratic) consensus. -
Date:05שלישינובמבר 2019הרצאה
Cooperative folding of polyglutamine helices in transcriptional regulators
More information שעה 14:00 - 14:00מיקום בניין הלן ומילטון קימלמןמרצה Dr. Xavier Salvatella מארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:06רביעינובמבר 2019הרצאה
Life Science Colloquium- Prof Feng Zhang
More information שעה 11:00 - 12:00כותרת Exploration of Microbial Diversity for Genome Editing and Beyondמיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה TBD צרו קשר -
Date:06רביעינובמבר 2019הרצאה
Boron subphthalocyanines and subnaphthalocyanines for organic photovoltaics
More information שעה 11:00 - 12:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Tim Bender
Department of Chemical Engineering and Applied Chemistry University of Torontoמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about For some time, our group has been focused on the design, syn...» For some time, our group has been focused on the design, synthesis and application of derivatives of boron subphthalocyanines (BsubPcs), a macrocyclic molecule with chelated central boron atom. Our focal point has been and continues to be equally balanced between the basic and applied chemistry of BsubPcs, their application as light absorbing and electronic conducting materials in organic photovoltaics (OPVs)/solar cells.
For this presentation I will outline how we have developed BsubPcs for their application in OPVs and other organic electronic devices. For OPVs, we have developed an approach to their development whereby their basic and applied chemistry is justified by a development cycle which includes their physical chemistry and characterization, their immediate integration into OPVs and based on their indoor stability are placed in the ambient environment to truly address their ultimate application in organic solar cells. Integrated into this cycle is a computational modeling methodology that is used to screen potential BsubPcs for their application in organic electronic devices including OPVs/organic solar cells. Most recently we have identified a pathway to BsubPcs whereby all carbons are bio-sourced and I will highlight how the computational model justified the time and resource commitment to their synthesis and development.
In addition to BsubPcs, we have taken an equal approach to extended -conjugated derivatives of BsubPcs, boron subnaphthalocyanines (BsubNcs); BsubNcs being unique and beneficial materials for OPV application. We have shown that BsubNcs actually become randomly chlorinated during their synthetic preparation and actually then form a mixed alloy composition of chlorinated materials, which we have designated as Cl-ClnBsubNcs. The mixed alloy composition is unique, and has been determined to be a mixture of 24 (more or less) chlorinated BsubNcs despite being a mixture that uniquely forms single crystals. The formation of single crystals is enabled by the chlorine atoms occupying vacancies within the solid state structure, the vacancies being the so-called “bay position” of the BsubNcs structure. During this presentation I will highlight how odd the mixed alloy composition of organic materials is and how hard it has been to separate the mixed alloyed composition. I will also highlight how we are moving forward with purposefully making mixed alloyed compositions of our macrocyclic compounds BsubPcs and BsubNcs fully justified by the potential performance increase in organic solar cells.
Co-authors/investigators will be identified during this presentation.
#--
Some Relevant References.
[1] “Outdoor Performance and Stability of Boron Subphthalocyanines Applied as Electron Acceptors in Fullerene-Free Organic Photovoltaics.” Josey, D.; et al, ACS Energy Lett., 2017, 2(3), 726–732. DOI: 10.1021/acsenergylett.6b00716.
[2] “Boron Subphthalocyanines as Electron Donors in Outdoor Lifetime Monitored Organic Photovoltaic Cells.” Garner, R.K.; et al, Solar Energy Materials and Solar Cells, 2018 176, 331-335. DOI: 10.1016/j.solmat.2017.10.018
[3] “8.4% efficient fullerene-free organic solar cells exploiting long-range exciton energy transfer” Cnops, K.; et al., Nature Comm., 5, Article number: 3406, DOI:10.1038/ncomms4406.
[4] “The mixed and alloyed chemical composition of chloro-(chloro)n-boron subnaphthalocyanines dictates their physical properties and performance in organic photovoltaics.” Dang, J.D.; et al, J. Mat. Chem. A., 2016, 4, 9566-9577. DOI: 10.1039/C6TA02457B
[5] “Phenoxy-(chloro)n-boron subnaphthalocyanines; alloyed mixture, electron-accepting functionality, enhanced solubility for bulk heterojunction organic photovoltaics” Dang, J.D.; et al, ACS Omega, 2018, 3(2), 2093–2103. DOI: 10.1021/acsomega.7b01892.
[6] “The Mixed Alloyed Chemical Composition of Chloro-(chloro)n-Boron Subnaphthalocyanines Dictates Their Performance as Electron-Donating and Hole-Transporting Materials in Organic Photovoltaics” Garner, R.K.; et al, ACS Appl. Energy Materials, 2017, 1(3), 1029-1036. DOI: 10.1021/acsaem.7b00180.
[7] "Outdoor Stability of Chloro-(Chloro)n-Boron Subnaphthalocyanine and Chloro-Boron Subphthalocyanine as Electron Acceptors in Bilayer and Trilayer Organic Photovoltaics" Josey, D.; et al, ACS Applied Energy Materials, 2019, 2(2), 979–986. DOI:10.1021/acsaem.8b01918