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April 28, 2015
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Date:07TuesdayJuly 2015Lecture
"Search for high mass diboson resonances with boson-tagged jets" Theory
More information Time 12:30 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Yotam Soreq
WeizmannOrganizer Department of Particle Physics and AstrophysicsContact -
Date:07TuesdayJuly 2015Cultural Events
Children's Theater
More information Time 17:30 - 19:00Title HaPil SheRatza Lihyot HachiLocation Michael Sela AuditoriumContact -
Date:08WednesdayJuly 2015Lecture
G-INCPM-Seminar - Dr. Jacob Hanna, Dept. of Molecular Genetics, Weizmann Institute - "Molecular Mechanisms for Assembling and Resolving Distinct Pluripotent States"
More information Time 11:00 - 12:30Location Nancy and Stephen Grand Israel National Center for Personalized MedicineLecturer Dr. Jacob Hanna
The Department of Molecular Genetics, Weizmann InstituteOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about The identity of somatic and pluripotent cells can be epigene...» The identity of somatic and pluripotent cells can be epigenetically reprogrammed and forced to adapt a new functional cell state by different methods and distinct combinations of exogenous factors. The aspiration to utilize such ex vivo reprogrammed pluripotent and somatic cells for therapeutic purposes necessitates understanding of the mechanisms of reprogramming and elucidating the extent of equivalence of the in vitro derived cells to their in vivo counterparts. In my presentation, I will present my group’s recent advances toward understanding these fundamental questions and further detail our ongoing efforts to generate developmentally unrestricted human naive pluripotent cells. I will conclude by highlighting new avenues for utilizing epigenetic reprogramming to naïve pluripotency for unraveling critical gene regulatory mechanisms acting during early mammalian development and highlighting prospects for new platforms for human disease and developmental modelling. -
Date:09ThursdayJuly 2015Lecture
Virology club meeting
More information Time 12:00 - 13:00Title TYLCV (Tomato yellow leaf curl virus) and its anti-host defense factor V2Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Yedidya Gafni Contact -
Date:09ThursdayJuly 2015Cultural Events
Adir Miller - Stand Up
More information Time 20:30 - 22:00Location Michael Sela AuditoriumContact -
Date:12SundayJuly 2015Lecture
Time-multiplexing for single- and multi-photon quantum state engineering
More information Time 13:15 - 14:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer Paul Kwiat Organizer Department of Physics of Complex SystemsContact -
Date:13MondayJuly 2015Lecture
Predicting cancer vulnerabilities via data-driven detection of synthetic lethality
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof. Eytan Ruppin
Tel-Aviv University & University of MarylandOrganizer Department of Immunology and Regenerative BiologyContact -
Date:16ThursdayJuly 2015Lecture
Magnetic Resonance Seminar
More information Time 09:30 - 09:30Title Changing MR Contrast with RF Irradiation: CEST and Myelin ImagingLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof Robert Lenkinski
Department of Radiology UT Southwestern Medical Center Dallas, TexasOrganizer Department of Chemical and Biological PhysicsContact -
Date:16ThursdayJuly 2015Lecture
Astronomy for All
More information Time 20:00 - 22:45Location Edna and K.B. Weissman Building of Physical SciencesLecturer Dr. David Polishook
WISOrganizer Department of Particle Physics and AstrophysicsContact -
Date:21TuesdayJuly 2015Lecture
Ab-initio theory of emission spectra from gain media
More information Time 13:15 - 14:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer Adi Pick
Massachusetts Institute of Technology (MIT)Organizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about We present an ab-initio theory which yields quantitatively a...» We present an ab-initio theory which yields quantitatively accurate formulas for the emission spectra from gain media, accounting for inhomogeneity and nonlinearity of the gain and including systems with exceptional points (EPs). Nonorthogonality of the modes in open resonators leads to enhancement of the local density of states and, consequently, to enhanced spontaneous emission rates. Traditional expressions for the enhancement (Petermann) formally diverge at EPs. However, by using an appropriate choice of basis vectors (including Jordan vectors), we show that the enhancement is actually finite. Moreover, the spectral lineshape near the resonance peaks changes from a simple Lorentzian for non-degenerate eigenvalues to a squared Lorentzian near EPs. Above the lasing thresholds, our analysis produces a generalized formula for the multimode laser linewidths that contains nearly all previously known effects and also finds new nonlinear and multimode corrections which become significant in microcavity lasers (e.g., random lasers and photonic-crystal lasers). -
Date:23ThursdayJuly 2015Lecture
Host-microbiota-Pathogens interactions in C. elegans: Determinism in shaping of the gut microbiota and its implications
More information Time 10:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Michael Shapira
Dept. of Integrative Biology, University of California, BerkleyContact -
Date:23ThursdayJuly 2015Cultural Events
Music and Astrophysics in a "Journey Among The Stars"
More information Time 19:30 - 21:00Location Michael Sela AuditoriumContact -
Date:28TuesdayJuly 2015Lecture
Exploring neuro-glio-vascular interactions through in vivo imaging of the mouse brain
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Jaime Grutzendler, MD
Dept of Neurology, Yale UniversityOrganizer Department of Brain SciencesContact Abstract Show full text abstract about I will discuss several lines of research in our lab utilizin...» I will discuss several lines of research in our lab utilizing high resolution in vivo and fixed tissue imaging to explore physiological and pathological mechanisms in the brain. Specifically we will discuss recent observations regarding mechanisms of neurovascular coupling and the role of smooth muscle cells versus pericytes in vasomotor responses after neural stimulation. We will also discuss findings related to a novel mechanism of microvascular recanalization that we termed angiophagy that could have potential important roles in stroke pathogenesis. Finally we will present a new method that we developed for high resolution label-free in vivo imaging of individual cortical myelinated axons that is allowing studies of myelin development and pathology. -
Date:28TuesdayJuly 2015Lecture
New Attosecond Spectroscopies for Correlation-Induced Electron Hole Dynamics
More information Time 13:15 - 14:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer Vitali Averbukh
Imperial College LondonOrganizer Department of Physics of Complex SystemsContact -
Date:29WednesdayJuly 2015Lecture
PacBio SMRT Sequencing overview
More information Time 09:30 - 09:30Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Amos Grundwag, Eisenberg Bros. Ltd. Organizer Department of Molecular GeneticsContact Abstract Show full text abstract about Recent advancements in our understanding of biological compl...» Recent advancements in our understanding of biological complexity have propelled the development of new tools. In the field of DNA and RNA sequencing, next-generation sequencers have dramatically increased productivity and provided novel insights into the structure and function of the genome. The PacBio RS II sequencing technology resolves single molecules in real time, allowing observation of structural and cell type variation not accessible with other technologies. These unique capabilities of the PacBio RS II system are ideally suited for a variety of applications, from De Novo assembly and targeted sequencing to detecting base modifications. -
Date:31FridayJuly 2015Cultural Events
Hip Hop Musical - The City
More information Time 21:00 - 22:45Location Michael Sela AuditoriumHomepage Contact -
Date:02SundayAugust 2015Cultural Events
Alilot Yichie beTailand
More information Time 21:00 - 22:30Location Michael Sela AuditoriumHomepage Contact -
Date:03MondayAugust 2015Lecture
Co-translational assembly constrains the structure and folding of homomeric proteins
More information Time 09:30 - 10:30Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Eviatar Natan
MRC Cambridge University UKOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Homomers are pervasive protein complexes in most proteomes t...» Homomers are pervasive protein complexes in most proteomes that involved in all major cellular functions. The three steps in homomer formation are: translation by the ribosome, folding, and assembly into a protein complex. We hypothesize that the relative rates of these three steps are crucial to avoid misassembly in the context of the high nascent chain concentration of the polysome, i.e., the super-complex of multiple translating ribosomes from same mRNA molecule. To examine this, we tested a library of constructs that differ, among other properties, in the N- versus C-terminal position of the assembly (oligomerization) domain. By analyzing the misassembly rates of these constructs in vivo, in vitro and in silico, and by computationally analyzing thousands of native homomers, we show a set of spatiotemporal constraints that act to preserve the integrity of homomers. In conclusion, our results suggest that there has been significant selection in evolution to maintain a balance between translation and assembly. -
Date:04TuesdayAugust 2015Lecture
Solution-Based Electronic Materials: from Flexible Electronics to Cellular Interfaces
More information Time 11:00 - 12:00Location Helen and Milton A. Kimmelman BuildingLecturer Prof. Myung-Han Yoon Organizer Department of Molecular Chemistry and Materials ScienceContact -
Date:05WednesdayAugust 2015Lecture
G-INCPM Seminar - Dr. Eran Elinav, Dept. of Immunology, Weizmann Institute - "Host Microbiome Interactions in Health and Disease"
More information Time 11:00 - 12:30Location Nancy and Stephen Grand Israel National Center for Personalized MedicineLecturer Prof. Eran Elinav
The Department of Immunology, Weizmann InstituteOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about The mammalian intestine contains trillions of microbes, a co...» The mammalian intestine contains trillions of microbes, a community that is dominated by members of the domain Bacteria but also includes members of Archaea, Eukarya, and viruses. The vast repertoire of this microbiome functions in ways that benefit the host. The mucosal immune system co-evolves with the microbiota beginning at birth, acquiring the capacity to tolerate components of the community while maintaining the capacity to respond to invading pathogens. The gut microbiota is shaped and regulated by multiple factors including our genomic composition, the local intestinal niche and multiple environmental factors including our nutritional repertoire and bio-geographical location. Moreover, it has been recently highlighted that dysregulation of these genetic or environmental factors leads to aberrant host-microbiome interactions, ultimately predisposing to pathologies ranging from chronic inflammation, obesity, the metabolic syndrome and even cancer. We have identified various possible mechanisms participating in the reciprocal regulation between the host and the intestinal microbial ecosystem, and demonstrate that disruption of these factors, in mice and humans, lead to dysbiosis and susceptibility to common multi-factorial disease. Understanding the molecular basis of host-microbiome interactions may lead to development of new microbiome-targeting treatments.