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אפריל 27, 2017
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Date:27ראשוןמרץ 2022הרצאה
Life Sciences Senior Scientists day
More information שעה כל היוםכותרת For PIs in the LS facultiesמיקום Kibbutz Na'anמארגן הפקולטה לביוכימיה , הפקולטה לביולוגיהצרו קשר -
Date:27ראשוןמרץ 2022הרצאה
Decadal Climate Predictions Using Sequential Learning Algorithms
More information שעה 11:00 - 11:00מיקום https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09מרצה Golan Bel
Ben-Gurion University of the Negevמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר תקציר Show full text abstract about Decadal Climate Predictions Using Sequential Learning Algori...» Decadal Climate Predictions Using Sequential Learning Algorithms
Ensembles of climate models are commonly used to improve climate predictions and assess the
uncertainties associated with them. Weighting the models according to their performances holds the promise of further improving their predictions. Using an ensemble of climate model simulations from the CMIP5 decadal experiments, we quantified the total uncertainty associated with these predictions and the relative importance of model and internal uncertainties. Sequential learning algorithms (SLAs) were used to reduce the forecast errors and reduce the model uncertainties. The reliability of the SLA predictions was also tested, and the advantages and limitations of the different performance measures are discussed. The spatial distribution of the SLAs performance showed that they are skillful and better than the other forecasting methods over large continuous regions. This finding suggests that, despite the fact that each of the ensemble models is not skillful, the models were able to capture some physical processes that resulted in deviations from the climatology and that the SLAs enabled the extraction of this additional information. If time permits I will also present a method for estimating the uncertainties associated with ensemble predictions and demonstrate the resulting improved reliability.
References:
1. Improvement of climate predictions and reduction of their uncertainties using learning algorithms, Atmospheric Chemistry and Physics 15, 8631-8641 (2015).
2. Decadal climate predictions using sequential learning algorithms, Journal of Climate 29, 3787-3809 (2016).
3. The contribution of internal and model variabilities to the uncertainty in CMIP5 decadal climate predictions, Climate Dynamics 49, 3221 (2017).
4. Quantifying the uncertainties in an ensemble of decadal climate predictions. Journal of Geophysical Research: Atmospheres 122, 13,191–13,200 (2017).
5. Learning algorithms allow for improved reliability and accuracy of global mean surface temperature projections. Nature Communications 11, 451 (2020).
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Date:28שנימרץ 202230רביעימרץ 2022כנסים
From Basic Cancer Research to Innovative Therapies
More information שעה 08:00 - 08:00מיקום אודיטוריום מיכאל סלעיושב ראש Moshe Orenדף בית -
Date:29שלישימרץ 202231חמישימרץ 2022כנסים
The links between Plant Hydraulics and Ecosystem Hydrology
More information שעה 08:00 - 08:00יושב ראש Dan Yakirמארגן המחלקה למדעי כדור הארץ וכוכבי הלכת -
Date:29שלישימרץ 2022הרצאה
Microbial and Antimicrobial Amyloids in the Fight Against Infections
More information שעה 10:00 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Prof. Meytal Landau
Faculty of Biology - Technionמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Amyloids are protein fibers with unique and strong structure...» Amyloids are protein fibers with unique and strong structures, known mainly in the context of neurodegenerative diseases. Surprisingly, amyloid fibers are secreted by species across kingdoms of life, including by microorganisms, and helps their survival and activity. Our laboratory published the first molecular structures of functional bacterial amyloid fibrils, which serve as key “weapons” making infections more aggressive. This exposed new routes for the development of novel antivirulence drugs. In addition, we identified peptides produced across species that provide antimicrobial protection that form amyloid fibrils, and determined their first high resolution structures. This amyloid-antimicrobial link signifies a physiological role in neuroimmunity for human amyloids.
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Date:29שלישימרץ 2022הרצאה
Complex biogenic crystals made by unicellular algae are constructed with simple principles
More information שעה 11:30 - 12:30כותרת Member Seminarמיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Emanuel Avrahami
Assaf Gal labמארגן המחלקה למדעי הצמח והסביבהצרו קשר תקציר Show full text abstract about Coccoliths are exoskeletal plates, made of highly complex mi...» Coccoliths are exoskeletal plates, made of highly complex microscopic calcite (CaCO3) crystals with astonishing morphological variety, produced by unicellular algae called Coccolithophores. For decades, their complexity has made coccolith fabrication and its controls alluring to scientists from different fields. Coccoliths grow intracellularly in a specialized vesicle where they presumably interact with chiral additives in a stereospecific manner. Such specific interactions are thought to give rise to numerous crystallographic faces, that convey ultrastructural chirality and convolutedness. We investigated the large coccoliths of Calcidiscus leptoporus by extracting them from within the cells along their growth, imagining them with various electron microscopy techniques at high resolution, and rendering their 3D structure. Our morphological analysis revealed that as the crystals mature, they transition from isotropic rhombohedra to highly anisotropic shapes, while expressing only a single set of crystallographic faces. This observation profoundly challenges the involvement of chiral modifiers. The crystals’ growth pattern showed that their shape is attained via differential growth rates of symmetry related facets with. Additionally, the rhombohedral geometry of the crystals appears to convey ultrastructural chirality in initial coccolith assembly stages. These findings change our understanding of biological control over complex crystal construction and mechanistically simplify the system in which they emerge. -
Date:03ראשוןאפריל 202206רביעיאפריל 2022כנסים
Sexual dimorphism of neuronal circuits and behavior
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Meital Oren-Suissaדף בית -
Date:03ראשוןאפריל 2022הרצאה
Poachers, Mammals and Birds The Endless Story
More information שעה 13:00 - 14:00כותרת SAERI HYBRID Lecture- Sustainability and Energy Research Initiative lecture seriesמיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Prof. Gila Kahila Bar-Gal
Koret School of Veterinary Medicine The Robert H. Smith Faculty of Agriculture, Food & Environment The Hebrew University of Jerusalemמארגן בית הספר למחקר - מכון ויצמן למדעצרו קשר -
Date:05שלישיאפריל 2022הרצאה
Role of forces in membrane dynamics and tissue morphogenesis
More information שעה 10:00 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Prof. Marino Zerial
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germanyמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Our work has highlighted the function of Rab GTPases as key ...» Our work has highlighted the function of Rab GTPases as key components for the biogenesis, transport and function of cellular membrane organelles. The specificity and directionality of membrane fusion is mediated by Rab GTPases and tethering effectors, such as EEA1, which is recruited on the early endosome membrane and binds to Rab5. EEA1 is a long dimeric coiled-coil tether molecule. Upon binding to its N-terminus, Rab5 induces conformational changes on EEA1, from extended to a more flexible “collapsed” state, giving rise to an effective force. Our recent studies suggest that Rab5 and EEA1 effectively constitute a two-component molecular motor, cyclically converting the free energy of GTP binding and hydrolysis into mechanical work. We are now combining biochemical, quantitative image analysis and 3D primary cell culture approaches to explore the role of Rab GTPases and endocytic mechanisms in liver tissue organization and regeneration. Hepatocytes are polarized cells at the interface of both sinusoidal endothelial and bile canaliculi (BC) networks that transport blood and bile between portal and central vein, respectively. In contrast to simple epithelia, where the cells have a single apical surface facing the lumen of organs, hepatocytes exhibit a multipolar (biaxial) organization, i.e. have multiple apical and basal domains. We studied the mechanism of hepatocyte polarization by using a hepatoblasts culture system. We discovered that, during lumen formation, hepatoblasts create apical protrusions along the tight junction belt that connects them, suggesting that these are responsible for the anisotropic growth of apical lumina. These protrusions form a pattern reminiscent of the bulkheads of boats ships and planes. Similarly, the apical bulkheads of hepatocytes are structural elements which can provide such anisotropy and mechanical stability to the elongating cylindrical lumen under inner pressure. -
Date:05שלישיאפריל 2022הרצאה
Decoupling floral transition and Apical Dominance in tomato
More information שעה 11:30 - 12:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומארגן המחלקה למדעי הצמח והסביבהצרו קשר תקציר Show full text abstract about In plants, primary growth is sustained by a shoot apical mer...» In plants, primary growth is sustained by a shoot apical meristem (SAM) that produce lateral leaf organs from their flanks until floral transition is attained. At this point, the SAM is marked by a dramatic doming of the SAM followed by either lateral formation of flowers e.g: Arabidopsis or by termination of by a flower as in determinate plants like tomato. Irrespective of the developmental track at the shoot apex, floral transition in both growth types is followed by the release of basal axillary buds from Apical Dominance, cues that are regularly emitted by the vegetative SAM. We use tomato shoot apices to understand the molecular changes that are triggered at floral transition by exhaustively profiling transcriptomes of individual SAMs. To that end, we identified dynamic, successive, transient gene expression programs activated along the developmental progression of SAM. I will present our results on how - genetic interrogation of components of these transient gene programs allowed dissociation of the tightly linked process of floral transition and apical dominance release. The relevance of these gene programs for flexibility to form simple to highly compound inflorescence structures will be discussed. -
Date:05שלישיאפריל 2022הרצאה
Conscious intentions during voluntary action formation
More information שעה 12:30 - 13:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Uri Maoz
Computational Neuroscience Chapman University Visiting Assistant Professor-UCLA Visiting Associate-Caltechמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about Investigating conscious intentions associated with spontaneo...» Investigating conscious intentions associated with spontaneous, voluntary action is challenging. Typical paradigms inherently lack the stimulus-response structure that is common in neuroscientific tasks (Haggard, 2019). Moreover, studying the onset of intentions has proven notoriously difficult, conceptually and empirically. Measuring the onset of intentions with a clock was shown to be inconsistent, biased, and unreliable (Maoz et al., 2015). Furthermore, probe methods estimated intention onset much earlier than clock-based methods (Matsuhashi & Hallett, 2008), complicating the reconciliation of these results. Some have even questioned the existence of intentions as discrete, causal neural states (Schurger & Utihol, 2015).
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Date:05שלישיאפריל 2022הרצאה
The Impact of DNA damages on Protein-DNA Interactions
More information שעה 14:00 - 15:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Ariel Afek
Dept. of Chemical and Structural Biology Weizmann Instituteמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:06רביעיאפריל 2022הרצאה
Tissue level insights from cellular measurements – Identifying multi-cellular hubs in colorectal cancer
More information שעה כל היוםמיקום בניין ע"ש מקס ולילאן קנדיוטימארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:07חמישיאפריל 2022הרצאה
New advances at the G-INCPM Bioinformatics unit
More information שעה 09:00 - 10:00מיקום ZOOMמרצה Dr. Danny Ben-Avraham
G-INCPM Bioinformatics Unitמארגן המחלקה לתשתיות מחקר מדעי החייםדף בית צרו קשר -
Date:07חמישיאפריל 2022הרצאה
Special guest seminar with Prof. Kent Søe
More information שעה 13:30 - 14:30כותרת Heterogeneity of human osteoclasts from a cellular to a patient perspectiveמיקום בניין ארתור ורושל בלפר למחקר ביורפואימארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:07חמישיאפריל 2022הרצאה
The microbiome as part of the tumor ecosystem
More information שעה 14:00 - 15:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Prof. Ravid Straussman
Department of Molecular Cell Biology • Faculty of Biologyמארגן המכון לחקר הטיפול בסרטן עש דואקצרו קשר -
Date:10ראשוןאפריל 2022הרצאה
WIS-Q Seminar
More information שעה 13:00 - 13:00כותרת How Quantum Computing is Changing Cryptographyמיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Prof. Zvika Brakerski מארגן המחלקה לפיזיקה של חומר מעובהצרו קשר תקציר Show full text abstract about It is fairly well known that Shor's algorithm for Facto...» It is fairly well known that Shor's algorithm for Factoring and Discrete Logarithm poses a challenge for cryptography in a quantum world. However, the implications of the viability of the quantum model on cryptography are much more profound, on a number of aspects. Naturally, it is harder to protect against quantum attackers than against classical ones, especially if the honest users remain classical. On the other hand, quantum computation and communication also present new tools that may assist in performing some cryptographic tasks. Further, the quantum model brings about new potential capabilities and cryptographic tasks that need to be explored, most basically the ability to prove that a potentially untrusted device indeed performs a quantum task.
In the talk I will explain how computer scientists, and in particular cryptographers, perceive the quantum computing model. I will discuss some of the fundamental questions that come up when the quantum model is incorporated into cryptography, such as the security of "lattice assumptions" against quantum attacks, the rewinding problem in cryptographic reductions, and the notion of semi-quantum cryptography which addresses questions in classical-quantum interaction.
No background in computer science or cryptography will be assumed.
Hybrid seminar
Location: Physics library (Benoziyo Physics building, second floor)
Zoom link: https://weizmann.zoom.us/j/99771276053?pwd=K3N6NEpPemh6aDZ2dEpJUU5HRXo4UT09
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Date:10ראשוןאפריל 2022הרצאה
Insights on hypermutation in cancer initiation and response to immunotherapy. Lessons from a rare cancer syndrome
More information שעה 14:00 - 15:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Prof. Uri Tabori
Garron Family Chair in childhood cancer research. Professor of Paediatrics and Medical Biophysics University of Toronto Senior Scientist, Research Institute and The Arthur and Sonia Labatt Brain Tumour Research Centreמארגן המכון לחקר הטיפול בסרטן עש דואקצרו קשר -
Date:11שניאפריל 2022כנסים
Quantum Leap: How Quantum Computing is Advancing from Lab to Industry
More information שעה 16:30 - 20:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Sharon Fireman -
Date:12שלישיאפריל 2022כנסים
Israel Crystallographic Association Annual Meeting 2022
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Ron Diskin
