לוח שנה משולב

Time irreversibility is the hallmark of nonequilibrium dissipative processes. Detecting dissipation is essential for our basic understanding of the underlying physical mechanism, however, it remains a challenge in the absence of observable directed motion, flows, or fluxes. Additional difficulty arises in complex systems where many internal degrees of freedom are inaccessible to an external observer. In living systems, for example, the dissipation is directly related to the hydrolysis of fuel molecules such as adenosine triphosphate (ATP), whose consumption rate is difficult to directly measure in many experimental setups. In this talk, I will introduce a novel approach to detect time irreversibility and estimate the entropy production from time-series measurements, even in the absence of observable currents. This method can be implemented in scenarios where only partial information is available and thus provides a new tool for studying nonequilibrium phenomena.


1. G. Bisker et al. Inferring broken detailed balance in the absence of observable currents,
Nature Communications, 10(1), 1-10 (2019)
2. G. Bisker et al. Hierarchical Bounds on Entropy Production Inferred from Partial
Information, Journal of Statistical Mechanics: Theory and Experiment (9), 093210 (2017)

Cardiovascular disease is a result of genetic and environmental risk factors that together generate arterial and cardiac pathologies. Blood vessels connect multiple organ systems throughout the entire body allowing organs to interact via circulating messengers. Multimodality imaging achieves integration of these interfacing systems’ distinct processes, quantifying interactions that contribute to cardiovascular disease. Noninvasive multimodality imaging techniques are emerging tools that can further our understanding of this complex and dynamic interplay. Multichannel multimodality imaging including optics, CT, PET and MRI, are particularly promising because they can simultaneously sample multiple biomarkers. As the opportunities provided by imaging expand, mapping interconnected systems will help us decipher the complexity of cardiovascular disease and monitor novel therapeutic strategies.