Bioinformatics: LSCF About

Bioinformatics Unit

Is devoted to advancing scientific understanding of living systems through computation. The unit promotes and supports the adoption, use, and development of bioinformatics tools for advancing biological research. We organize and teach courses and workshops for all our services, as well as train individually. Since bioinformatics is such a broad field, our efforts are focused on those topics that are most needed by Weizmann researchers.
The Bioinformatics Unit is supported by the Wertheimer Center for Computational Biology.

 

Data Analysis & Programming

Support is available for complete analyses, and for teaching researchers/students how to analyze their results independently. We encourage researchers to consult us when planning a project.

Click on the analysis titles  below for detailed information.

Next-generation sequencing and third generation sequencing analysis and interpretation including single cell analysis - Dr. Dena Leshkowitz, Dr. Ester Feldmesser, Dr. Gil Stelzer, Dr. Bareket Dassa and Dr. Noa Wigoda

The advent of deep sequencing platforms has opened exciting new avenues to life science researchers. Our aim is to help you in experimental design and interpretation of the massive data generated by your scientific interests. . Pipelines that we develop are available for researchers to run in our UTAP web application. Our current expertise is in the following applications:

  • Bulk transcriptome analysis: RNA-Seq (short and long reads), Mars-seq, SCRB-Seq, Ribo-Seq and small RNA-Seq
  • Single cell RNA-Seq (scRNA) and multiome single cell analysis: scATAC-Seq, CITE-Seq and immune profiling.
  • Epigenomics analysis: ChIP-Seq and cut & run.
  • De novo assembly (RNA and DNA level) using long (ONT and Pacbio) and short reads.
  • Genetic variation detection
  • Downstream analysis including pathways and networks analysis.

We will be happy to extend our knowledge in this dynamic field, and provide analysis for additional application types.

 

 

CRISPR design - Dr. Shifra Ben-Dor and Dr. Noa Wigoda

Designing CRISPR guides for various types of analyses and checking the results.

Classic Bioinformatics and Genomics - Dr. Shifra Ben-Dor

This topic includes all of the classical bioinformatics problems, including troubleshooting Sanger sequencing, cloning design, primer design, database searches, multiple alignments, prediction of post-translational modifications, phylogenetic analysis and promoter analysis.

 

 

Biostatistical Support - Dr. Ron Rotkopf

We provide biostatistical support at different stages of the experiment. Yet, we encourage researchers to consult a statistician early in the planning stage of a project, discussing aspects of experimental design, sample size calculations, organization of data, statistical analysis of the results, presentation and interpretation.

Machine learning and Artificial Intelligence - Dr. Ido Azuri

The usage of artificial intelligence manifests today almost in every field, and found to be a successful tool for many applications. We provide deep learning, machine learning and AI in numerous applications, such as: medical informatics - examining patients records in order to discover complex relations, genomics - recognizing functional patterns in data, proteomics  prediction of protein folding, structure, and function, and more.

Programming Departmental LIMS: Dr. Jaime Prilusky, Michal Twik and Itzik Bruchim

Developing applications to support the laboratory management and thier interface with clients.

Programming Pipelines for Next-generation sequencing - UTAP: Jordana Lindner

Developing and maintaining a user friendly interface UTAP, available for Weizmann researchers to run many NGS pipelines designed by our unit members.  This pipeline is also utilized for teaching purposes.  utap@weizmann.ac.il