Metabolic Profiling Publications

  1. Rosenberg G., Yehezkel D., Hoffman D., Ciolli Mattioli C., Fremder M., Ben-Arosh H., Vainman L., Nissani N., Hen-Avivi S., Brenner S., Itkin M., Malitsky S., Ohana E., Ben-Moshe N. B. & Avraham R. (2021). Host succinate is an activation signal for Salmonella virulence during intracellular infection.  Science. 2021 Jan , 371 (6527):400-405.
  2. Gnainsky Y., Zfanya N., Elgart M., Omri E., Brandis A., Mehlman T., Itkin M., Malitsky S., Adamski J. & Soen Y. (2021). Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes.  Cell Reports. 2021 Jan , 34 (1).
  3. Kugler A., Kumari P., Kokabi K., Itkin M., Malitsky S. & Khozin-Goldberg I. (2020). Resilience to Freezing in the Vegetative Cells of the Microalga Lobosphaera incisa (Trebouxiophyceae, Chlorophyta).  Journal of Phycology. 2020 Jan , (2):334-345.
  4. Ziv C., Kumar D., Sela N., Itkin M., Malitsky S., Schaffer A. A. & Prusky D. B. (2020). Sugar-regulated susceptibility of tomato fruit to Colletotrichum and Penicillium requires differential mechanisms of pathogenicity and fruit responses.  Environmental Microbiology. 2020 Apr , (7):2870-2891.
  5. Rabinovich S., Silberman A., Adler L., Agron S., Levin-Zaidman S., Bahat A., Porat Z., Ben-Zeev E., Geva I., Itkin M., Malitsky S., Buchaklian A., Helbling D., Dimmock D. & Erez A. (2020). The mitochondrial carrier Citrin plays a role in regulating cellular energy during carcinogenesis.  Oncogene. 2020 Jan , 39 (1):164-175.
  6. Keshet R., Lee J. S., Adler L., Iraqi M., Ariav Y., Lim L. Q. J., Lerner S., Rabinovich S., Oren R., Katzir R., Tishler H. W., Stettner N., Goldman O., Landesman H., Galai S., Kuperman Y., Kuznetsov Y., Brandis A., Mehlman T., Malitsky S., Itkin M., Koehler S. E., Zhao Y., Talsania K., Shen T., Peled N., Ulitsky I., Porgador A., Ruppin E. & Erez A. (2020). Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors.  Nature Cancer. 2020 Sept , 1 (9):894-908.
  7. Kokabi K., Gorelova O., Zorin B., Didi-Cohen S., Itkin M., Malitsky S., Solovchenko A., Boussiba S. & Khozin-Goldberg I. (2020). Lipidome Remodeling and Autophagic Respose in the Arachidonic-Acid-Rich Microalga Lobosphaera incisa Under Nitrogen and Phosphorous Deprivation.  Frontiers in Plant Science. 2020 Nov , 11 .
  8. Gabay G., Faigenboim A., Dahan Y., Izhaki Y., Itkin M., Malitsky S., Elkind Y. & Flaishman M. A. (2019). Transcriptome analysis and metabolic profiling reveal the key role of alpha-linolenic acid in dormancy regulation of European pear.  Journal of Experimental Botany. 2019 Jan , 70 (3):1017-1031.
  9. Kokabi K., Gorelova O., Ismagulova T., Itkin M., Malitsky S., Boussiba S., Soloychenko A. & Khozin-Goldberg I. (2019). Metabolomic foundation for differential responses of lipid metabolism to nitrogen and phosphorus deprivation in an arachidonic acid-producing green microalga.  Plant Science. 2019 Jun , 283 :95-115.
  10. Lee J. S., Adler L., Karathia H., Carmel N., Rabinovich S., Auslander N., Keshet R., Stettner N., Silberman A., Agemy L., Helbling D., Eilam R., Sun Q., Brandis A., Malitsky S., Itkin M., Weiss H., Pinto S., Kalaora S., Levy R., Barnea E., Admon A., Dimmock D., Stern-Ginossar N., Scherz A., Nagamani S. C. S., Unda M., Wilson D. M., Elhasid R., Carracedo A., Samuels Y., Hannenhalli S., Ruppin E. & Erez A. (2018). Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.  Cell. 2018 Sept , 174 (6):1559-1570.
  11. Nir I., Shohat H., Panizel I., Olszewski N., Aharoni A. & Weiss D. (2017). The Tomato DELLA Protein PROCERA Acts in Guard Cells to Promote Stomatal Closure.  Plant Cell. 2017 Dec , 29 (12):3186-3197.
  12. Paudel J. R., Davidson C., Song J., Maxim I., Aharoni A. & Tai H. H. (2017). Pathogen and Pest Responses Are Altered Due to RNAi-Mediated Knockdown of GLYCOALKALOID METABOLISM 4 in Solanum tuberosum.  Molecular Plant-Microbe Interactions. 2017 Nov , 30 (11):876-885.
  13. Cohen H., Hacham Y., Panizel I., Rogachev I., Aharoni A. & Amir R. (2017). Repression of CYSTATHIONINE gamma-SYNTHASE in Seeds Recruits the S-Methylmethionine Cycle.  Plant Physiology. 2017 Jul , 174 :1322-1333.
  14. Lashbrooke J., Cohen H., Levy-Samocha D., Tzfadia O., Panizel I., Zeisler V., Massalha H., Stern A., Trainotti L., Schreiber L., Costa F. & Aharoni A. (2016). MYB107 and MYB9 Homologs Regulate Suberin Deposition in Angiosperms.  Plant Cell. 2016 Sept , 28 (9):2097-2116.
  15. Breitel D. A., Chappell-Maor L., Meir S., Panizel I., Puig C. P., Hao Y., Yifhar T., Yasuor H., Zouine M., Bouzayen M., Richart A. G., Rogachev I. & Aharoni A. (2016). AUXIN RESPONSE FACTOR 2 Intersects Hormonal Signals in the Regulation of Tomato Fruit Ripening.  PLoS Genetics. 2016 Mar , 12 (3).
  16. Itkin M., Davidovich-Rikanati R., Cohen S., Portnoy V., Doron-Faigenboim A., Oren E., Freilich S., Tzuri G., Baranes N., Shen S., Petreikov M., Sertchook R., Ben-Dor S., Gottlieb H., Hernandez A., Nelson D., Paris H., Tadmor Y., Burger Y., Lewinsohn E., Katzir N. & Schaffer A. (2016). The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.  Proceedings of the National Academy of Sciences of the United States of America. 2016 Nov , 113 (47):E7619-E7628.
  17. Cohen S., Itkin M., Yeselson Y., Tzuri G., Portnoy V., Harel-Baja R., Lev S., Sa'ar U., Davidovitz-Rikanati R., Baranes N., Bar E., Wolf D., Petreikov M., Shen S., Ben-Dor S., Rogachev I., Aharoni A., Ast T., Schuldiner M., Belausov E., Eshed R., Ophir R., Sherman A., Frei B., Neuhaus H. E., Xu Y., Fei Z., Giovannoni J., Lewinsohn E., Tadmor Y., Paris H. S., Katzir N., Burger Y. & Schaffer A. A. (2014). The PH gene determines fruit acidity and contributes to the evolution of sweet melons.  Nature Communications. 2014 Jun , 5 .
  18. Itkin M., Heinig U., Tzfadia O., Bhide A. J., Shinde B. A., Cardenas P. D., Bocobza S. E., Unger T., Malitsky S., Finkers R., Tikunov Y., Bovy A., Chikate Y. R., Singh P., Rogachev I., Beekwilder J., Giri A. P. & Aharoni A. (2013). Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops Is Mediated by Clustered Genes.  Science. 2013 Jul , 341 (6142):175-179.
  19. Cohen S., Tzuri G., Harel-Beja R., Itkin M., Portnoy V., Sa'ar U., Lev S., Yeselson L., Petrikov M., Rogachev I., Aharoni A., Ophir R., Tadmor Y., Lewinsohn E., Burger Y., Katzir N. & Schaffer A. A. (2012). Co-mapping studies of QTLs for fruit acidity and candidate genes of organic acid metabolism and proton transport in sweet melon (Cucumis melo L.).  Theoretical And Applied Genetics. 2012 Jul , 125 (2):343-353.
  20. Itkin M., Rogachev I., Alkan N., Rosenberg T., Malitsky S., Masini L., Meir S., Iijima Y., Aoki K., de Vos V. R., Prusky D., Burdman S., Beekwilder J. & Aharoni A. (2011). GLYCOALKALOID METABOLISM1 Is Required for Steroidal Alkaloid Glycosylation and Prevention of Phytotoxicity in Tomato.  Plant Cell. 2011 Dec , 23 (12):4507-4525.