Crystallization, Structural Determination and Structure Modeling Publications

  1. Wein T., Millman A., Lange K., Yirmiya E., Hadary R., Garb J., Melamed S., Amitai G., Dym O., Steinruecke F., Hill A. B., Kranzusch P. J. & Sorek R. (2025). CARD domains mediate anti-phage defence in bacterial gasdermin systems.  Nature. 2025 Mar 20 , 639 (8055):727-734.
  2. Mizrachi A., Sadeh M., Ben-Dor S., Dym O., Ku C., Feldmesser E., Zarfin A., Brunson J. K., Allen A. E., Jinkerson R. E., Schatz D. & Vardi A. (2025). Cathepsin X is a conserved cell death protein involved in algal response to environmental stress.  Current Biology. 2025 Apr 14 , 35 (10):2240-2255.e6.
  3. Peer L., Dym O., Elad N., Tirosh A., Jacobovitch J., Sivan E., Angel M., Albeck S., Schuldiner M., Peleg Y. & Zalckvar E. (2025). A cryo-electron microscopy structure of yeast Pex5 in complex with a cargo uncovers a novel binding interface.  Journal of Cell Science. 2025 Jun , 138 (12).
  4. Listov D., Vos E., Hoffka G., Hoch S. Y., Berg A., Hamer-Rogotner S., Dym O., Kamerlin S. C. L. & Fleishman S. J. (2025). Complete computational design of high-efficiency Kemp elimination enzymes.  Nature. 2025 Jun 18 , 643 (8074):1421-1427.
  5. Chaturvedi A. K., Dym O., Levin Y. & Fluhr R. (2024). PGR5-LIKE PHOTOSYNTHETIC PHENOTYPE1A redox states alleviate photoinhibition during changes in light intensity.  Plant Physiology. 2024 Feb , 194 (2):1059-1074.
  6. Yeshaya N., Gupta P. K., Dym O., Morgenstern D., Major D. T. & Fass D. (2024). VWD domain stabilization by autocatalytic Asp-Pro cleavage.  Protein Science. 2024 Mar , 33 (3).
  7. Dym O., Aggarwal N., Ashani Y., Leader H., Albeck S., Unger T., Hamer-Rogotner S., Silman I., Tawfik D. S. & Sussman J. L. (2023). The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.  Acta Crystallographica Section D: Structural Biology. 2023 Nov , 79 (Pt 11):992-1009.
  8. Khersonsky O., Goldsmith M., Zaretsky I., Hamer-Rogotner S., Dym O., Unger T., Yona M., Fridmann-Sirkis Y. & Fleishman S. J. (2023). Stable Mammalian Serum Albumins Designed for Bacterial Expression.  Journal of Molecular Biology. 2023 Sept 1 , 435 (17).
  9. Rezenman S., Knafo M., Tsigalnitski I., Barad S., Jona G., Levi D., Dym O., Reich Z. & Kapon R. (2023). gUMI-BEAR, a modular, unsupervised population barcoding method to track variants and evolution at high resolution.  PLoS ONE. 2023 Jun 7 , 18 (6):e0286696.
  10. Gould N. L., Scherer G. R., Carvalho S., Shurrush K., Kayyal H., Edry E., Elkobi A., David O., Foqara M., Thakar D., Pavesi T., Sharma V., Walker M., Maitland M., Dym O., Albeck S., Peleg Y., Germain N., Babaev I., Sharir H., Lalzar M., Shklyar B., Hazut N., Khamaisy M., Lévesque M., Lajoie G., Avoli M., Amitai G., Lefker B., Subramanyam C., Shilton B., Barr H. & Rosenblum K. (2023). Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimers disease phenotype in mice.  Journal of Clinical Investigation. 2023 Oct 2 , 133 (19).
  11. Khmelnitsky L., Milo A., Dym O. & Fass D. (2023). Diversity of CysD domains in gel-forming mucins.  FEBS Journal. 2023 Nov , 290 (21):5196-5203.
  12. Scheerer D., Adkar B. V., Bhattacharyya S., Levy D., Iljina M., Riven I., Dym O., Haran G. & Shakhnovich E. I. (2023). Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase.  Proceedings of the National Academy of Sciences of the United States of America. 2023, 120 (118).
  13. Shemi A., Ben-Dor S., Rotkopf R., Dym O. & Vardi A. (2023). Phylogeny and biogeography of the algal DMS-releasing enzyme in the global ocean.  ISME Communications. 2023 Jul 14 , 3 .
  14. Pokorna S., Khersonsky O., Lipsh-Sokolik R., Goldenzweig A., Nielsen R., Ashani Y., Peleg Y., Unger T., Albeck S., Dym O., Tirosh A., Tarayra R., Hocquemiller M., Laufer R., Ben-Dor S., Silman I., Sussman J. L., Fleishman S. J. & Futerman A. H. (2023). Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification.  FEBS Journal. 2023 Jul , 290 (13):3383-3399.
  15. Goldsmith M., Barad S., Peleg Y., Albeck S., Dym O., Brandis A., Mehlman T. & Reich Z. (2022). The identification and characterization of an oxalyl-CoA synthetase from grass pea (Lathyrus sativus L.).  RSC Chemical Biology. 2022 Mar 1 , 3 (3):320-333.
  16. Allouche-Arnon H., Khersonsky O., Tirukoti N. D., Peleg Y., Dym O., Albeck S., Brandis A., Mehlman T., Avram L., Harris T., Yadav N. N., Fleishman S. J. & Bar-Shir A. (2022). Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression.  Nature Biotechnology. 2022 Jul , 40 (7):1143-1149.
  17. Goldsmith M., Barad S., Knafo M., Savidor A., Ben-Dor S., Brandis A., Mehlman T., Peleg Y., Albeck S., Dym O., Ben-Zeev E., Barbole R. S., Aharoni A. & Reich Z. (2022). Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea.  Journal of Biological Chemistry. 2022 May 1 , 298 (5).
  18. Saikia C., Altman-Gueta H., Dym O., Karbat I. & Reuveny E. (2022). Conkunitzin-C2 from Conus consors induces an incomplete block of the Shaker K+ channel using a unique mode of action.  Biophysical Journal. 2022 Feb 11 , 121 (3(1)):500a-500a.
  19. Saikia C., Dym O., Altman-Gueta H., Gordon D., Reuveny E. & Karbat I. (2021). A Molecular Lid Mechanism of K+ Channel Blocker Action Revealed by a Cone Peptide.  Journal of Molecular Biology. 2021 Aug 20 , 433 (17).
  20. Mohan V., Gaffney J. P., Solomonov I., Levin M., Klepfish M., Akbareian S., Grünwald B., Dym O., Eisenstein M., Yu K. H., Kelsen D. P., Krüger A., Edwards D. R. & Sagi I. (2021). Conformation-specific inhibitory anti-mmp-7 monoclonal antibody sensitizes pancreatic ductal adenocarcinoma cells to chemotherapeutic cell kill.  Cancers. 2021 Apr 1 , 13 (7).