Metabolic Profiling Publications

  1. Adamovich Y., Dandavate V., Ezagouri S., Manella G., Zwighaft Z., Sobel J., Kuperman Y., Golik M., Auerbach A., Itkin M., Malitsky S. & Asher G. (2021). Clock proteins and training modify exercise capacity in a daytime-dependent manner.  Proceedings of the National Academy of Sciences - PNAS. 2021 Aug 31 , 118 (35).
  2. Heinemann-Yerushalmi L., Bentovim L., Felsenthal N., Vinestock R. C., Michaeli N., Krief S., Silberman A., Cohen M., Ben-Dor S., Brenner O., Haffner-Krausz R., Itkin M., Malitsky S., Erez A. & Zelzer E. (2021). BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development.  Developmental Cell. 2021 Apr 19 , 56 (8):1182-1194.e6.
  3. Bendikov-Bar I., Malitsky S., Itkin M., Rusal M. & Sagi D. (2021). Metabolomic Changes Are Predictive of Aging in Laying Hens.  The journals of gerontology. Series A, Biological sciences and medical sciences. 2021 May 12 , 76 (10):1757-1768.
  4. Rabinovich S., Silberman A., Adler L., Agron S., Levin-Zaidman S., Bahat A., Porat Z., Ben-Zeev E., Geva I., Itkin M., Malitsky S., Buchaklian A., Helbling D., Dimmock D. & Erez A. (2020). The mitochondrial carrier Citrin plays a role in regulating cellular energy during carcinogenesis.  Oncogene. 2020 Jan 2 , 39 (1):164-175.
  5. Kokabi K., Gorelova O., Zorin B., Didi-Cohen S., Itkin M., Malitsky S., Solovchenko A., Boussiba S. & Khozin-Goldberg I. (2020). Lipidome Remodeling and Autophagic Respose in the Arachidonic-Acid-Rich Microalga Lobosphaera incisa Under Nitrogen and Phosphorous Deprivation.  Frontiers in Plant Science. 2020 Nov 27 , 11 .
  6. Ziv C., Kumar D., Sela N., Itkin M., Malitsky S., Schaffer A. A. & Prusky D. B. (2020). Sugar-regulated susceptibility of tomato fruit to Colletotrichum and Penicillium requires differential mechanisms of pathogenicity and fruit responses.  Environmental Microbiology. 2020 Apr 22 , (7):2870-2891.
  7. Keshet R., Lee J. S., Adler L., Iraqi M., Ariav Y., Lim L. Q. J., Lerner S., Rabinovich S., Oren R., Katzir R., Tishler H. W., Stettner N., Goldman O., Landesman H., Galai S., Kuperman Y., Kuznetsov Y., Brandis A., Mehlman T., Malitsky S., Itkin M., Koehler S. E., Zhao Y., Talsania K., Shen T., Peled N., Ulitsky I., Porgador A., Ruppin E. & Erez A. (2020). Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors.  Nature Cancer. 2020 Sept , 1 (9):894-908.
  8. Kugler A., Kumari P., Kokabi K., Itkin M., Malitsky S. & Khozin-Goldberg I. (2020). Resilience to Freezing in the Vegetative Cells of the Microalga Lobosphaera incisa (Trebouxiophyceae, Chlorophyta).  Journal of Phycology. 2020 Jan 3 , (2):334-345.
  9. Gabay G., Faigenboim A., Dahan Y., Izhaki Y., Itkin M., Malitsky S., Elkind Y. & Flaishman M. A. (2019). Transcriptome analysis and metabolic profiling reveal the key role of alpha-linolenic acid in dormancy regulation of European pear.  Journal of Experimental Botany. 2019 Jan 30 , 70 (3):1017-1031.
  10. Kokabi K., Gorelova O., Ismagulova T., Itkin M., Malitsky S., Boussiba S., Soloychenko A. & Khozin-Goldberg I. (2019). Metabolomic foundation for differential responses of lipid metabolism to nitrogen and phosphorus deprivation in an arachidonic acid-producing green microalga.  Plant Science. 2019 Jun , 283 :95-115.
  11. Lee J. S., Adler L., Karathia H., Carmel N., Rabinovich S., Auslander N., Keshet R., Stettner N., Silberman A., Agemy L., Helbling D., Eilam R., Sun Q., Brandis A., Malitsky S., Itkin M., Weiss H., Pinto S., Kalaora S., Levy R., Barnea E., Admon A., Dimmock D., Stern-Ginossar N., Scherz A., Nagamani S. C. S., Unda M., Wilson D. M., Elhasid R., Carracedo A., Samuels Y., Hannenhalli S., Ruppin E. & Erez A. (2018). Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.  Cell. 2018 Sept 6 , 174 (6):1559-1570.
  12. Paudel J. R., Davidson C., Song J., Maxim I., Aharoni A. & Tai H. H. (2017). Pathogen and Pest Responses Are Altered Due to RNAi-Mediated Knockdown of GLYCOALKALOID METABOLISM 4 in Solanum tuberosum.  Molecular Plant-Microbe Interactions. 2017 Nov , 30 (11):876-885.
  13. Nir I., Shohat H., Panizel I., Olszewski N., Aharoni A. & Weiss D. (2017). The Tomato DELLA Protein PROCERA Acts in Guard Cells to Promote Stomatal Closure.  Plant Cell. 2017 Dec , 29 (12):3186-3197.
  14. Cohen H., Hacham Y., Panizel I., Rogachev I., Aharoni A. & Amir R. (2017). Repression of CYSTATHIONINE gamma-SYNTHASE in Seeds Recruits the S-Methylmethionine Cycle.  Plant Physiology. 2017 Jul , 174 :1322-1333.
  15. Itkin M., Davidovich-Rikanati R., Cohen S., Portnoy V., Doron-Faigenboim A., Oren E., Freilich S., Tzuri G., Baranes N., Shen S., Petreikov M., Sertchook R., Ben-Dor S., Gottlieb H., Hernandez A., Nelson D., Paris H., Tadmor Y., Burger Y., Lewinsohn E., Katzir N. & Schaffer A. (2016). The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.  Proceedings of the National Academy of Sciences of the United States of America. 2016 Nov , 113 (47):E7619-E7628.
  16. Lashbrooke J., Cohen H., Levy-Samocha D., Tzfadia O., Panizel I., Zeisler V., Massalha H., Stern A., Trainotti L., Schreiber L., Costa F. & Aharoni A. (2016). MYB107 and MYB9 Homologs Regulate Suberin Deposition in Angiosperms.  Plant Cell. 2016 Sept , 28 (9):2097-2116.
  17. Breitel D. A., Chappell-Maor L., Meir S., Panizel I., Puig C. P., Hao Y., Yifhar T., Yasuor H., Zouine M., Bouzayen M., Richart A. G., Rogachev I. & Aharoni A. (2016). AUXIN RESPONSE FACTOR 2 Intersects Hormonal Signals in the Regulation of Tomato Fruit Ripening.  PLoS Genetics. 2016 Mar 9 , 12 (3).
  18. Cohen S., Itkin M., Yeselson Y., Tzuri G., Portnoy V., Harel-Baja R., Lev S., Sa'ar U., Davidovitz-Rikanati R., Baranes N., Bar E., Wolf D., Petreikov M., Shen S., Ben-Dor S., Rogachev I., Aharoni A., Ast T., Schuldiner M., Belausov E., Eshed R., Ophir R., Sherman A., Frei B., Neuhaus H. E., Xu Y., Fei Z., Giovannoni J., Lewinsohn E., Tadmor Y., Paris H. S., Katzir N., Burger Y. & Schaffer A. A. (2014). The PH gene determines fruit acidity and contributes to the evolution of sweet melons.  Nature Communications. 2014 Jun , 5 .
  19. Itkin M., Heinig U., Tzfadia O., Bhide A. J., Shinde B. A., Cardenas P. D., Bocobza S. E., Unger T., Malitsky S., Finkers R., Tikunov Y., Bovy A., Chikate Y. R., Singh P., Rogachev I., Beekwilder J., Giri A. P. & Aharoni A. (2013). Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops Is Mediated by Clustered Genes.  Science. 2013 Jul , 341 (6142):175-179.
  20. Cohen S., Tzuri G., Harel-Beja R., Itkin M., Portnoy V., Sa'ar U., Lev S., Yeselson L., Petrikov M., Rogachev I., Aharoni A., Ophir R., Tadmor Y., Lewinsohn E., Burger Y., Katzir N. & Schaffer A. A. (2012). Co-mapping studies of QTLs for fruit acidity and candidate genes of organic acid metabolism and proton transport in sweet melon (Cucumis melo L.).  Theoretical And Applied Genetics. 2012 Jul , 125 (2):343-353.