Protein Analysis Publications

  1. Shimon L. J., Rabinkov A., Shin I., Miron T., Mirelman D., Wilchek M. & Frolow F. (2007). Two Structures of Alliinase from Alliium sativum L.: Apo Form and Ternary Complex with Aminoacrylate Reaction Intermediate Covalently Bound to the PLP Cofactor.  Journal of Molecular Biology. 2007 Feb 16 , 366 (2):611-625.
  2. Lorin A., Charloteaux B., Fridmann-Sirkis Y., Thomas A., Shai Y. & Brasseur R. (2007). Mode of membrane interaction and fusogenic properties of a de novo transmembrane model peptide depend on the length of the hydrophobic core.  Journal of Biological Chemistry. 2007 Jun 22 , 282 (25):18388-18396.
  3. Horovitz A., Fridmann Y., Kafri G. & Yifrach O. (2006). Allostery in chaperonins.  Rendiconti Lincei. 2006 Mar , 17 (1-2):115-131.
  4. Zik M., Fridmann Sirkis S. Y. & Fromm H. (2006). C-terminal residues of plant glutamate decarboxylase are required for oligomerization of a high-molecular weight complex and for activation by calcium/calmodulin.  Biochimica Et Biophysica Acta-Proteins And Proteomics. 2006 May , 1764 (5):872-876.
  5. Gonen A., Harats D., Rabinkov A., Miron T., Mirelman D., Wilchek M., Weiner L., Ulman E., Levkovitz H., Ben-Shushan D. & Shaish A. (2006). The antiatherogenic effect of allicin: Possible mode of action.  Pathobiology. 2006 Apr , 72 (6):325-334.
  6. Miron T., SivaRaman H., Rabinkov A., Mirelman D. & Wilchek M. (2006). A method for continuous production of allicin using immobilized alliinase.  Analytical Biochemistry. 2006 Apr 1 , 351 (1):152-154.
  7. Novick D., Rubinstein M., Azam T., Rabinkov A., Dinarello C. & Kim S. (2006). Proteinase 3 is an IL-32 binding protein.  Proceedings of the National Academy of Sciences of the United States of America. 2006 Feb 28 , 103 (9):3316-3321.
  8. Arditti F., Rabinkov A., Miron T., Reisner Y., Berrebi A., Wilchek M. & Mirelman D. (2005). Apoptotic killing of B-chronic lymphocytic leukemia tumor cells by allicin generated in situ using a rituximab-alliinase conjugate.  Molecular Cancer Therapeutics. 2005 Feb 15 , 4 (2):325-331.
  9. Oron-Herman M., Rosenthal T., Mirelman D., Miron T., Rabinkov A., Wilchek M. & Sela B. (2005). The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome.  Atherosclerosis. 2005 Dec , 183 (2):238-243.
  10. Miron T., Rabinkov A., Peleg E., Rosenthal T., Mirelman D. & Wilchek M. (2004). Allylmercaptocaptopril: A New Antihypertensive Drug.  American Journal of Hypertension. 2004 Jan , 17 (1):71-73.
  11. Sela U., Ganor S., Hecht I., Brill A., Miron T., Rabinkov A., Wilchek M., Mirelman D., Lider O. & Hershkoviz R. (2004). Allicin inhibits SDF-1α-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression.  Immunology. 2004 Apr , 111 (4):391-399.
  12. Miron T., Bercovici T., Rabinkov A., Wilchek M. & Mirelman D. (2004). [3H]Allicin: Preparation and applications.  Analytical Biochemistry. 2004 Aug 15 , 331 (2):364-369.
  13. Patya M., Zahalka M. A., Vanichkin A., Rabinkov A., Miron T., Mirelman D., Wilchek M., Lander H. M. & Novogrodsky A. (2004). Allicin stimulates lymphocytes and elicits an antitumor effect: A possible role of p21ras.  International Immunology. 2004 Feb , 16 (2):275-281.
  14. Shadkchan Y., Shemesh E., Mirelman D., Miron T., Rabinkov A., Wilchek M. & Osherov N. (2004). Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis.  Journal of Antimicrobial Chemotherapy. 2004 May , 53 (5):832-836.
  15. Millard C., Shnyrov V., Newstead S., Shin I., Roth E., Silman I. & Weiner L. (2003). Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones.  Protein Science. 2003 Oct 1 , 12 (10):2337-2347.
  16. Elkayam A., Mirelman D., Peleg E., Wilchek M., Miron T., Rabinkov A., Oron-Herman M. & Rosenthal T. (2003). The Effects of Allicin on Weight in Fructose-Induced Hyperinsulinemic, Hyperlipidemic, Hypertensive Rats.  American Journal of Hypertension. 2003 Dec , 16 (12):1053-1056.
  17. Miron T., Mironchik M., Mirelman D., Wilchek M. & Rabinkov A. (2003). Inhibition of tumor growth by a novel approach: In situ allicin generation using targeted alliinase delivery.  Molecular Cancer Therapeutics. 2003 Dec , 2 (12):1295-1301.
  18. Miron T., Shin I., Feigenblat G., Weiner L., Mirelman D., Wilchek M. & Rabinkov A. (2002). A spectrophotometric assay for allicin, alliin, and alliinase (alliin lyase) with a chromogenic thiol: Reaction of 4-mercaptopyridine with thiosulfinates.  Analytical Biochemistry. 2002 Aug 1 , 307 (1):76-83.
  19. Shimon L., Rabinkov A., Miron T., Mirelman D., Wilchek M. & Frolow F. (2002). Alliin lyase (alliinase) from garlic (Allium sativum): Crystallization and preliminary X-ray characterization.  Acta Crystallographica Section D: Biological Crystallography. 2002, 58 (8):1335-1337.
  20. Shin I., Wachtel E., Roth E., Bon C., Silman I. & Weiner L. (2002). Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding?.  Protein Science. 2002, 11 (8):2022-2032.