Crystallisation and Structure Determination Publications

  1. Yadid I., Kirshenbaum N., Sharon M., Dym O. & Tawfik D. (2010). Metamorphic proteins mediate evolutionary transitions of structure.  Proceedings of the National Academy of Sciences of the United States of America. 2010 Apr , 107 (16):7287-7292.
  2. Goihberg E., Peretz M., Tel-Or S., Dym O., Shimon L., Frolow F. & Burstein Y. (2010). Biochemical and Structural Properties of Chimeras Constructed by Exchange of Cofactor-Binding Domains in Alcohol Dehydrogenases from Thermophilic and Mesophilic Microorganisms.  Biochemistry. 2010 Mar , 49 (9):1943-1953.
  3. Grossman M., Tworowski D., Dym O., Lee M., Levy Y., Murphy G. & Sagi I. (2010). The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function.  Biochemistry. 2010 Jul , 49 (29):6184-6192.
  4. Levin K. B., Dym O., Albeck S., Magdassi S., Keeble A. H., Kleanthous C. & Tawfik D. (2009). Following evolutionary paths to protein-protein interactions with high affinity and selectivity.  Nature Structural & Molecular Biology. 2009 Oct , 16 (10):1049-U67.
  5. Dym O., Albeck S., Peleg Y., Schwarz A., Shakked Z., Burstein Y. & Zimhony O. (2009). Structure-Function Analysis of the Acyl Carrier Protein Synthase (AcpS) from Mycobacterium tuberculosis.  Journal of Molecular Biology. 2009 Nov , 393 (4):937-950.
  6. Liberman N., Dym O., Unger T., Albeck S., Peleg Y., Jacobovitch Y., Branzburg A., Eisenstein M., Marash L. & Kimchi A. (2008). The Crystal Structure of the C-Terminal DAP5/p97 Domain Sheds Light on the Molecular Basis for Its Processing by Caspase Cleavage.  Journal of Molecular Biology. 2008 Nov , 383 (3):539-548.
  7. Dym O., Albeck S., Unger T., Jacobovitch J., Brainzburg A., Michael Y., Frenkiel-Krispin D., Wolf S. G. & Elbaum M. (2008). Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners.  Proceedings of the National Academy of Sciences of the United States of America. 2008 Aug , 105 (32):11170-11175.
  8. Manicka S., Peleg Y., Unger T., Albeck S., Dym O., Greenblatt H. A., Bourenkov G., Lamzin V., Krishnaswamy S. & Sussman J. (2008). Crystal structure of yagE, a putative DHDPS-like protein from Escherichia coli K12.  Proteins-Structure Function And Bioinformatics. 2008 Jun , 71 (4):2102-2108.
  9. Rothlisberger D., Khersonsky O., Wollacott A. M., Jiang L., DeChancie J., Betker J., Gallaher J. L., Althoff E. A., Zanghellini A., Dym O., Albeck S., Houk K. N., Tawfik D. & Baker D. (2008). Kemp elimination catalysts by computational enzyme design.  Nature. 2008 May , 453 (7192):190-U4.
  10. Goihberg E., Dym O., Tel-Or S., Shimon L., Frolow F., Peretz M. & Burstein Y. (2008). Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution.  Proteins-Structure Function And Bioinformatics. 2008 Aug , 72 (2):711-719.
  11. Cohen S., Dym O., Albeck S., Ben-Dov E., Cahan R., Firer M. & Zaritsky A. (2008). High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp israelensis.  Journal of Molecular Biology. 2008 Jul , 380 (5):820-827.
  12. , Graslund S., Peleg Y., Albeck S., Unger T., Dym O., Prilusky J. & Sussman J. L. (2008). Protein production and purification.  Nature Methods. 2008 Feb , 5 (2):135-146.
  13. Albeck S., Dym O., Unger T., Snapir Z., Bercovich Z. & Kahana C. (2008). Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function.  Protein Science. 2008 May , 17 (5):793-802.
  14. Reichmann D., Cohen M., Abramovich R., Dym O., Lim D., Strynadka N. C. J. & Schreiber G. (2007). Binding hot spots in the TEM1-BLIP interface in light of its modular architecture.  Journal of Molecular Biology. 2007 Jan , 365 (3):663-679.
  15. Shaaltiel Y., Bartfeld D., Hashmueli S., Baum G., Brill-Almon E., Galili G., Dym O., Boldin-Adamsky S. A., Silman I., Sussman J., Futerman A. H. & Aviezer D. (2007). Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.  Plant Biotechnology Journal. 2007 Sept , 5 (5):579-590.
  16. Goihberg E., Dym O., Tel-Or S., Levin I., Peretz M. & Burstein Y. (2007). A single proline substitution is critical for the thermostabilization of Clostridium beijerinckii alcohol dehydrogenase.  Proteins-Structure Function And Bioinformatics. 2007 Jan , 66 (1):196-204.
  17. Berry I. M., Dym O., Esnouf R. M., Harlos K., Meged R., Perrakis A., Sussman J., Walter T. S., Wilson J. & Messerschmidt A. (2006). Spine High-Throughput Crystallization, Crystal Imaging And Recognition Techniques: Current State, Performance Analysis, New Technologies And Future Aspects.  Acta Crystallographica Section D-Biological Crystallography. 2006 Oct , 62 :1137-1149.
  18. Asher G., Dym O., Tsvetkov P., Adler J. & Shaul Y. (2006). The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.  Biochemistry. 2006 May , 45 (20):6372-6378.
  19. Fogg M. J., Alzari P., Bahar M., Bertini I., Betton J. -., Burmeister W. P., Cambillau C., Canard B., Carrondo M., Coll M., Daenke S., Dym O., Egloff M. -., Enguita F. J., Geerlof A., Haouz A., Jones T. A., Ma Q. & Manicka S. N. (2006). Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.  Acta Crystallographica Section D-Biological Crystallography. 2006 Oct , 62 :1196-1207.
  20. Albeck S., Alzari P., Andreini C., Banci L., Berry I. M., Bertini I., Cambillau C., Canard B., Carter L., Cohen S. X., Diprose J. M., Dym O., Esnouf R. M., Felder C., Ferron F., Guillemot F., Hamer R., Ben Jelloul J. M., Laskowski R. A., Laurent T., Longhi S., Lopez R., Luchinat C., Malet H., Mochel T., Morris R. J., Moulinier L., Oinn T., Pajon A., Peleg Y., Perrakis A., Poch O., Prilusky J., Rachedi A., Ripp R., Rosato A., Silman I., Stuart D. I., Sussman J., Thierry J. -., Thompson J. D., Thornton J. M., Unger T., Vaughan B., Vranken W., Watson J. D., Whamond G. & Henrick K. (2006). Spine Bioinformatics And Data-Management Aspects Of High-Throughput Structural Biology.  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. 2006 Oct , 62 :1184-1195.